MacroMind matchup data: real ranked games, not opinions
Cassiopeia vs Seraphine
Cassiopeia vs Seraphine in Mid: who wins more often?
Across 27 ranked games in Mid, Cassiopeia beats Seraphine in 48% of them.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Cassiopeia ahead by 471 gold.
Cassiopeia at 15:00
- Gold: +471
- CS: +1
- XP: +240
Typical gap to Seraphine, from 27 games that reached 15:00.
Your Cassiopeia game plan against Seraphine
In the median game here, the first death comes near 5:54 and level 6 lands around 5:35. Until your spike is online, treat the all-in window with respect.
Cassiopeia in Mid: the items that actually get built
The most-finished Cassiopeia core is Rod of Ages, Archangel's Staff, Rylai's Crystal Scepter: 54.2% across 2,129 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Ring + Health Potion + Health Potion; the first finished item is usually Rod of Ages (5,513 games).
Skill plan: Cassiopeia players max E first and take E at level 1.