MacroMind matchup data: real ranked games, not opinions
Vayne vs Seraphine
How often does Vayne beat Seraphine in ADC?
Vayne into Seraphine in ADC: 46% observed win rate across 445 ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 3 gold.
Vayne at 15:00
- Gold: -3
- CS: -1
- XP: -334
Typical gap to Seraphine, from 445 games that reached 15:00.
Does Vayne counter Seraphine?
No counter here: Vayne sits at 46% over 445 games. The swing lives in the spots below, so play the side you know better and chase the row that moves the number the most in this lane, then hold that lead through the first back.
Beating Seraphine: the Vayne game plan
A gold lead at 10:00 puts Vayne at 53% across 232 games. Flip the lead and Vayne falls to 38% across 213.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 53% | 232 |
| Behind in gold at 10:00 | 38% | 213 |
| First blood | 52% | 236 |
| +kills at 10:00 | 52% | 178 |
| +CS at 10:00 | 50% | 210 |
| 0 deaths at 10:00 | 64% | 85 |
Someone usually dies here around 4:54 in the median game, and level 6 lands near 7:37. Until your spike is online, respect the all-in.
Vayne's ADC build, with receipts
Into Seraphine specifically, Vayne finishes Blade of The Ruined King first most often: 43.4% over 76 games of this matchup.
The most-finished Vayne core is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 56.2% across 7,087 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Blade of The Ruined King (20,168 games).
Skill plan: Vayne players max Q first and take Q at level 1.