MacroMind matchup data: real ranked games, not opinions
Vayne vs Kai'Sa
How often does Vayne beat Kai'Sa in ADC?
Vayne into Kai'Sa in ADC: 52% observed win rate across 9,305 ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 269 gold.
Vayne at 15:00
- Gold: -269
- CS: -8
- XP: -134
Typical gap to Kai'Sa, from 9,245 games that reached 15:00.
Does Vayne counter Kai'Sa?
The count says yes: across 9,305 ranked ADC games into Kai'Sa, Vayne takes 52%. That edge is worth playing for. Check the rows below to see how much a gold lead at 10:00 adds, and what a bad start costs Vayne.
Beating Kai'Sa: the Vayne game plan
A gold lead at 10:00 puts Vayne at 63% across 4,098 games. Flip the lead and Vayne falls to 43% across 5,199.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 63% | 4,098 |
| Behind in gold at 10:00 | 43% | 5,199 |
| First blood | 58% | 4,782 |
| +kills at 10:00 | 64% | 3,570 |
| +CS at 10:00 | 62% | 3,225 |
| 0 deaths at 10:00 | 62% | 1,768 |
| 0 deaths at 15:00 | 71% | 607 |
Someone usually dies here around 4:38 in the median game, and level 6 lands near 7:43. Until your spike is online, respect the all-in.
Vayne's ADC build, with receipts
Into Kai'Sa specifically, Vayne finishes Blade of The Ruined King first most often: 49.1% over 1,927 games of this matchup.
The most-finished core in this exact matchup is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 54.0% across 729 games.
The most-finished Vayne core is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 56.2% across 7,087 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Blade of The Ruined King (20,168 games).
Skill plan: Vayne players max Q first and take Q at level 1.