MacroMind matchup data: real ranked games, not opinions
Vayne vs Senna
How often does Vayne beat Senna in ADC?
Vayne into Senna in ADC: 46% observed win rate across 1,549 ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 121 gold.
Vayne at 15:00
- Gold: -121
- CS: 0
- XP: -224
Typical gap to Senna, from 1,543 games that reached 15:00.
Does Vayne counter Senna?
The count says no. Senna holds 54% of 1,549 ranked ADC games here. The lane is still winnable. Vayne wins it back from the spots below, so learn which ones swing it before you lock in Vayne against Senna, and play for those first.
Beating Senna: the Vayne game plan
A gold lead at 10:00 puts Vayne at 56% across 752 games. Flip the lead and Vayne falls to 38% across 795.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 56% | 752 |
| Behind in gold at 10:00 | 38% | 795 |
| First blood | 51% | 866 |
| +kills at 10:00 | 53% | 726 |
| +CS at 10:00 | 53% | 752 |
| 0 deaths at 10:00 | 53% | 326 |
| 0 deaths at 15:00 | 64% | 111 |
Someone usually dies here around 5:11 in the median game, and level 6 lands near 7:40. Until your spike is online, respect the all-in.
Vayne's ADC build, with receipts
Into Senna specifically, Vayne finishes Blade of The Ruined King first most often: 47.0% over 411 games of this matchup.
The most-finished core in this exact matchup is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 55.4% across 148 games.
The most-finished Vayne core is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 56.2% across 7,087 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Blade of The Ruined King (20,168 games).
Skill plan: Vayne players max Q first and take Q at level 1.