MacroMind matchup data: real ranked games, not opinions
Senna vs Vayne
What is Senna's win rate vs Vayne?
In ADC, Senna wins 54% against Vayne across 1,549 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Senna ahead by 121 gold.
Senna at 15:00
- Gold: +121
- CS: 0
- XP: +224
Typical gap to Vayne, from 1,543 games that reached 15:00.
Does Senna counter Vayne?
Yes. Senna wins 54% of 1,549 ranked ADC games into Vayne. That is a real edge in this lane, so play for it. The 10:00 rows below show how often Senna closes the game out from a lead, and how often Vayne claws it back.
How to beat Vayne as Senna
When Senna is ahead in gold at 10:00, this matchup runs 62% over 795 games; behind, it drops to 45% over 752.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 62% | 795 |
| Behind in gold at 10:00 | 45% | 752 |
| First blood | 59% | 712 |
| +kills at 10:00 | 62% | 454 |
| +CS at 10:00 | 60% | 759 |
| 0 deaths at 10:00 | 59% | 429 |
| 0 deaths at 15:00 | 68% | 173 |
The median first death in this lane comes at 5:38; the level 6 spike lands around 7:31. Respect the all-in window until your spike is online.
What does Senna build in ADC?
Into Vayne specifically, Senna finishes Statikk Shiv first most often: 54.9% over 842 games of this matchup.
The most-finished core in this exact matchup is Statikk Shiv, Black Cleaver, Hexoptics C44: 57.8% across 263 games.
The most-finished Senna core is Statikk Shiv, Black Cleaver, Hexoptics C44: 58.4% across 10,501 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Statikk Shiv (32,740 games).
Skill plan: Senna players max Q first and take Q at level 1.