MacroMind matchup data: real ranked games, not opinions
Vayne vs Anivia
What is Vayne's win rate vs Anivia?
In Mid, Vayne wins 46% against Anivia across 28 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 435 gold.
Vayne at 15:00
- Gold: -435
- CS: -6
- XP: -860
Typical gap to Anivia, from 28 games that reached 15:00.
How to beat Anivia as Vayne
The median first death in this lane comes at 3:54; the level 6 spike lands around 5:58. Respect the all-in window until your spike is online.