MacroMind matchup data: real ranked games, not opinions
Vayne vs Zyra
What is Vayne's win rate vs Zyra?
In ADC, Vayne wins 39% against Zyra across 33 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 210 gold.
Vayne at 15:00
- Gold: -210
- CS: -5
- XP: -481
Typical gap to Zyra, from 33 games that reached 15:00.
How to beat Zyra as Vayne
The median first death in this lane comes at 6:31; the level 6 spike lands around 7:47. Respect the all-in window until your spike is online.
What does Vayne build in ADC?
The most-finished Vayne core is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 56.2% across 7,087 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Blade of The Ruined King (20,168 games).
Skill plan: Vayne players max Q first and take Q at level 1.