MacroMind matchup data: real ranked games, not opinions
Vayne vs Zeri
What is Vayne's win rate vs Zeri?
In ADC, Vayne wins 51% against Zeri across 1,443 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 334 gold.
Vayne at 15:00
- Gold: -334
- CS: -10
- XP: +11
Typical gap to Zeri, from 1,436 games that reached 15:00.
Does Vayne counter Zeri?
Too close to call. Vayne sits at 51% over 1,443 games, so neither pick counters the other here. The lane goes to whoever wins the spots below, like the gold lead at 10:00 or staying alive until 15:00, so play for those and let the pick argument go.
How to beat Zeri as Vayne
When Vayne is ahead in gold at 10:00, this matchup runs 65% over 682 games; behind, it drops to 39% over 760.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 65% | 682 |
| Behind in gold at 10:00 | 39% | 760 |
| First blood | 59% | 838 |
| +kills at 10:00 | 64% | 662 |
| +CS at 10:00 | 64% | 464 |
| 0 deaths at 10:00 | 62% | 345 |
| 0 deaths at 15:00 | 71% | 119 |
The median first death in this lane comes at 5:47; the level 6 spike lands around 7:37. Respect the all-in window until your spike is online.
What does Vayne build in ADC?
Into Zeri specifically, Vayne finishes Blade of The Ruined King first most often: 51.7% over 290 games of this matchup.
The most-finished core in this exact matchup is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 57.7% across 111 games.
The most-finished Vayne core is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 56.2% across 7,087 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Blade of The Ruined King (20,168 games).
Skill plan: Vayne players max Q first and take Q at level 1.