MacroMind matchup data: real ranked games, not opinions
Vayne vs Twisted Fate
What is Vayne's win rate vs Twisted Fate?
In Mid, Vayne wins 25% against Twisted Fate across 64 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 678 gold.
Vayne at 15:00
- Gold: -678
- CS: -2
- XP: -365
Typical gap to Twisted Fate, from 64 games that reached 15:00.
Does Vayne counter Twisted Fate?
No, it runs the other way. Twisted Fate takes 75% of 64 ranked Mid games. Vayne can still win it. The rows below show the spots that flip it, so plan your first recall and your trades around them, and play the lane for one of those spots rather than for kills.
How to beat Twisted Fate as Vayne
The median first death in this lane comes at 5:08; the level 6 spike lands around 5:31. Respect the all-in window until your spike is online.