MacroMind matchup data: real ranked games, not opinions
Vayne vs Ryze
What is Vayne's win rate vs Ryze?
In Mid, Vayne wins 52% against Ryze across 27 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 424 gold.
Vayne at 15:00
- Gold: -424
- CS: -12
- XP: -247
Typical gap to Ryze, from 26 games that reached 15:00.
How to beat Ryze as Vayne
The median first death in this lane comes at 3:30; the level 6 spike lands around 5:14. Respect the all-in window until your spike is online.