MacroMind matchup data: real ranked games, not opinions
Vayne vs Karthus
How often does Vayne beat Karthus in ADC?
Vayne into Karthus in ADC: 47% observed win rate across 213 ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 195 gold.
Vayne at 15:00
- Gold: -195
- CS: -7
- XP: -299
Typical gap to Karthus, from 213 games that reached 15:00.
Does Vayne counter Karthus?
No counter here: Vayne sits at 47% over 213 games. The swing lives in the spots below, so play the side you know better and chase the row that moves the number the most in this lane, then hold that lead through the first back.
Beating Karthus: the Vayne game plan
A gold lead at 10:00 puts Vayne at 61% across 97 games. Flip the lead and Vayne falls to 35% across 116.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 61% | 97 |
| Behind in gold at 10:00 | 35% | 116 |
| First blood | 52% | 113 |
| +kills at 10:00 | 60% | 87 |
| +CS at 10:00 | 57% | 84 |
Someone usually dies here around 3:32 in the median game, and level 6 lands near 7:42. Until your spike is online, respect the all-in.
Vayne's ADC build, with receipts
Into Karthus specifically, Vayne finishes Blade of The Ruined King first most often: 51.2% over 41 games of this matchup.
The most-finished Vayne core is Blade of The Ruined King, Guinsoo's Rageblade, Terminus: 56.2% across 7,087 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Blade of The Ruined King (20,168 games).
Skill plan: Vayne players max Q first and take Q at level 1.