MacroMind matchup data: real ranked games, not opinions
Syndra vs Vayne
What is Syndra's win rate vs Vayne?
In ADC, Syndra wins 55% against Vayne across 167 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Syndra ahead by 265 gold.
Syndra at 15:00
- Gold: +265
- CS: +10
- XP: +405
Typical gap to Vayne, from 167 games that reached 15:00.
Does Syndra counter Vayne?
Too close to call. Syndra sits at 55% over 167 games, so neither pick counters the other here. The lane goes to whoever wins the spots below, like the gold lead at 10:00 or staying alive until 15:00, so play for those and let the pick argument go.
How to beat Vayne as Syndra
When Syndra is ahead in gold at 10:00, this matchup runs 56% over 96 games; behind, it drops to 52% over 71.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 56% | 96 |
| Behind in gold at 10:00 | 52% | 71 |
| First blood | 56% | 89 |
| +kills at 10:00 | 64% | 44 |
| +CS at 10:00 | 56% | 97 |
| 0 deaths at 10:00 | 47% | 47 |
The median first death in this lane comes at 7:00; the level 6 spike lands around 7:11. Respect the all-in window until your spike is online.
What does Syndra build in ADC?
Into Vayne specifically, Syndra finishes Luden's Echo first most often: 48.8% over 43 games of this matchup.
The most-finished Syndra core is Luden's Echo, Shadowflame, Rabadon's Deathcap: 52.6% across 331 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Ring + Health Potion + Health Potion; the first finished item is usually Luden's Echo (1,134 games).
Skill plan: Syndra players max Q first and take Q at level 1.