MacroMind matchup data: real ranked games, not opinions
Cassiopeia vs Vayne
What is Cassiopeia's win rate vs Vayne?
In ADC, Cassiopeia wins 56% against Vayne across 79 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Cassiopeia ahead by 414 gold.
Cassiopeia at 15:00
- Gold: +414
- CS: +15
- XP: +523
Typical gap to Vayne, from 78 games that reached 15:00.
Does Cassiopeia counter Vayne?
Too close to call. Cassiopeia sits at 56% over 79 games, so neither pick counters the other here. The lane goes to whoever wins the spots below, like the gold lead at 10:00 or staying alive until 15:00, so play for those and let the pick argument go.
How to beat Vayne as Cassiopeia
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 66% | 44 |
| +CS at 10:00 | 61% | 49 |
The median first death in this lane comes at 4:28; the level 6 spike lands around 7:39. Respect the all-in window until your spike is online.