MacroMind matchup data: real ranked games, not opinions
Caitlyn vs Vayne
What is Caitlyn's win rate vs Vayne?
In ADC, Caitlyn wins 50% against Vayne across 6,674 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Caitlyn ahead by 600 gold.
Caitlyn at 15:00
- Gold: +600
- CS: +17
- XP: +204
Typical gap to Vayne, from 6,635 games that reached 15:00.
Does Caitlyn counter Vayne?
Too close to call. Caitlyn sits at 50% over 6,674 games, so neither pick counters the other here. The lane goes to whoever wins the spots below, like the gold lead at 10:00 or staying alive until 15:00, so play for those and let the pick argument go.
How to beat Vayne as Caitlyn
When Caitlyn is ahead in gold at 10:00, this matchup runs 57% over 4,324 games; behind, it drops to 37% over 2,349.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 57% | 4,324 |
| Behind in gold at 10:00 | 37% | 2,349 |
| First blood | 57% | 3,428 |
| +kills at 10:00 | 60% | 2,587 |
| +CS at 10:00 | 54% | 5,250 |
| 0 deaths at 10:00 | 60% | 1,428 |
| 0 deaths at 15:00 | 74% | 450 |
The median first death in this lane comes at 5:17; the level 6 spike lands around 7:21. Respect the all-in window until your spike is online.
What does Caitlyn build in ADC?
Into Vayne specifically, Caitlyn finishes Hexoptics C44 first most often: 51.6% over 1,451 games of this matchup.
The most-finished core in this exact matchup is The Collector, Infinity Edge, Lord Dominik's Regards: 54.0% across 533 games.
The most-finished Caitlyn core is The Collector, Infinity Edge, Lord Dominik's Regards: 54.3% across 14,626 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Hexoptics C44 (47,375 games).
Skill plan: Caitlyn players max Q first and take Q at level 1.