MacroMind matchup data: real ranked games, not opinions
Caitlyn vs Vayne
What is Caitlyn's win rate vs Vayne?
In Top, Caitlyn wins 39% against Vayne across 80 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Caitlyn ahead by 1,106 gold.
Caitlyn at 15:00
- Gold: +1,106
- CS: +28
- XP: +419
Typical gap to Vayne, from 80 games that reached 15:00.
Does Caitlyn counter Vayne?
No, it runs the other way. Vayne takes 61% of 80 ranked Top games. Caitlyn can still win it. The rows below show the spots that flip it, so plan your first recall and your trades around them, and play the lane for one of those spots rather than for kills.
How to beat Vayne as Caitlyn
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 39% | 59 |
| First blood | 29% | 41 |
| +CS at 10:00 | 40% | 67 |
The median first death in this lane comes at 4:37; the level 6 spike lands around 5:20. Respect the all-in window until your spike is online.