MacroMind matchup data: real ranked games, not opinions
Vayne vs Syndra
What is Vayne's win rate vs Syndra?
In Mid, Vayne wins 52% against Syndra across 50 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 856 gold.
Vayne at 15:00
- Gold: -856
- CS: -15
- XP: -849
Typical gap to Syndra, from 50 games that reached 15:00.
Does Vayne counter Syndra?
Too close to call. Vayne sits at 52% over 50 games, so neither pick counters the other here. The lane goes to whoever wins the spots below, like the gold lead at 10:00 or staying alive until 15:00, so play for those and let the pick argument go.
How to beat Syndra as Vayne
The median first death in this lane comes at 5:54; the level 6 spike lands around 5:31. Respect the all-in window until your spike is online.