MacroMind matchup data: real ranked games, not opinions
Vayne vs Pantheon
How often does Vayne beat Pantheon in Top?
Vayne into Pantheon in Top: 50% observed win rate across 375 ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Vayne behind by 645 gold.
Vayne at 15:00
- Gold: -645
- CS: -3
- XP: -602
Typical gap to Pantheon, from 373 games that reached 15:00.
Does Vayne counter Pantheon?
No counter here: Vayne sits at 50% over 375 games. The swing lives in the spots below, so play the side you know better and chase the row that moves the number the most in this lane, then hold that lead through the first back.
Beating Pantheon: the Vayne game plan
A gold lead at 10:00 puts Vayne at 61% across 115 games. Flip the lead and Vayne falls to 45% across 258.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 61% | 115 |
| Behind in gold at 10:00 | 45% | 258 |
| First blood | 55% | 98 |
| +kills at 10:00 | 62% | 73 |
| +CS at 10:00 | 58% | 164 |
Someone usually dies here around 3:12 in the median game, and level 6 lands near 6:02. Until your spike is online, respect the all-in.
Vayne's Top build, with receipts
Into Pantheon specifically, Vayne finishes Experimental Hexplate first most often: 45.8% over 83 games of this matchup.
The most-finished Vayne core is Blade of The Ruined King, Guinsoo's Rageblade, Experimental Hexplate: 58.0% across 1,282 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Blade of The Ruined King (8,972 games).
Skill plan: Vayne players max Q first and take Q at level 1.