MacroMind matchup data: real ranked games, not opinions
Mel vs Vayne
What is Mel's win rate vs Vayne?
In Top, Mel wins 59% against Vayne across 34 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Mel ahead by 928 gold.
Mel at 15:00
- Gold: +928
- CS: +21
- XP: +601
Typical gap to Vayne, from 34 games that reached 15:00.
How to beat Vayne as Mel
The median first death in this lane comes at 5:46; the level 6 spike lands around 5:33. Respect the all-in window until your spike is online.