MacroMind matchup data — real ranked games, not opinions
Karthus vs Zoe
In Mid, Karthus wins 44% against Zoe across 27 observed ranked games. This is an observed win rate shown with its sample size, not a prediction or a guaranteed counter.
By 15 minutes the median game has Karthus behind by 278 gold.
How to beat Zoe as Karthus
The median first death in this lane comes at 4:18; the level 6 spike lands around 5:16. Respect the all-in window until your spike is online.