MacroMind matchup data: real ranked games, not opinions
Kai'Sa vs Vayne
What is Kai'Sa's win rate vs Vayne?
In Top, Kai'Sa wins 48% against Vayne across 50 observed ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Kai'Sa ahead by 439 gold.
Kai'Sa at 15:00
- Gold: +439
- CS: +9
- XP: +67
Typical gap to Vayne, from 50 games that reached 15:00.
Does Kai'Sa counter Vayne?
Too close to call. Kai'Sa sits at 48% over 50 games, so neither pick counters the other here. The lane goes to whoever wins the spots below, like the gold lead at 10:00 or staying alive until 15:00, so play for those and let the pick argument go.
How to beat Vayne as Kai'Sa
The median first death in this lane comes at 5:05; the level 6 spike lands around 5:36. Respect the all-in window until your spike is online.