MacroMind matchup data: real ranked games, not opinions
Senna vs Karthus
How often does Senna beat Karthus in ADC?
Senna into Karthus in ADC: 46% observed win rate across 191 ranked games.
Global ranked sample: games from every region and every rank pooled together, not one server's stats. Data runs through patch 26.12; curves updated 2026-08-07.
By 15 minutes the median game has Senna behind by 867 gold.
Senna at 15:00
- Gold: -867
- CS: -22
- XP: -579
Typical gap to Karthus, from 191 games that reached 15:00.
Does Senna counter Karthus?
No counter here: Senna sits at 46% over 191 games. The swing lives in the spots below, so play the side you know better and chase the row that moves the number the most in this lane, then hold that lead through the first back.
Beating Karthus: the Senna game plan
A gold lead at 10:00 puts Senna at 57% across 63 games. Flip the lead and Senna falls to 40% across 128.
| The spot | Win rate | Games |
|---|---|---|
| Ahead in gold at 10:00 | 57% | 63 |
| Behind in gold at 10:00 | 40% | 128 |
| First blood | 52% | 82 |
| +kills at 10:00 | 58% | 48 |
| +CS at 10:00 | 52% | 46 |
Someone usually dies here around 4:02 in the median game, and level 6 lands near 7:37. Until your spike is online, respect the all-in.
Senna's ADC build, with receipts
Into Karthus specifically, Senna finishes Statikk Shiv first most often: 43.9% over 107 games of this matchup.
The most-finished Senna core is Statikk Shiv, Black Cleaver, Hexoptics C44: 58.4% across 10,501 games when all three got done. All matchups, patches 26.1-26.12.
Most games start Doran's Blade + Health Potion; the first finished item is usually Statikk Shiv (32,740 games).
Skill plan: Senna players max Q first and take Q at level 1.